Prior to Game 4, MLB introduced the Latino Legends Team. Performing the National Anthem, Jon Secada apparently was unable to change notes without adjusting his body position and inappropriately altered the lyrics accents.

Two outs into the top of the first, RF-R Jermaine Dye hit a line drive into centerfield for a double. 1B-R Paul Konerko grounded out, leaving Dye stranded at second. 2B-R Craig Biggio led off the bottom of the first with a groundball single into left field. CF-R Willy Taveras moved Biggio to second with a sacrifice bunt, but Chicago starter RHP Freddy Garcia did not allow Houston to drive him in.

Rising to World Series form, RHP Brandon Backe did not allow the White Sox a baserunner in the top of the second. Leading off the bottom of the second, 1B-L Mike Lamb thumped a flyball off the fence in right field for a double. However, Garcia struck out RF-R Jason Lane and C-R Brad Ausmus, and SS-R Adam Everett ended the inning with a groundout.

With two outs down in the top of the third, LF-L Scott Podsednik dropped a line drive into far right-center and stretched it into a triple. The effort proved fruitless when 2B-R Tadahito Iguchi grounded out to end the inning. Garcia went one-two-three through the bottom of the third, indicating that Game 4 might prove the pitchers' duel many anticipated would dominate most of the Series.

Backe gave up a lead off single to Dye in the fourth before striking out the White Sox's next three batters. LF-S Lance Berkman opened the bottom of the fourth with a walk, but the Astros were unable to take second base. After 3B-R Morgan Ensberg struck out, first Lamb and then Lane grounded into fielders' choice plays in which Chicago knocked off the lead runner.

Both 3B-R Joe Crede and SS-R Juan Uribe fell to strikeouts before Backe permitted Garcia to make the trip down to first base on a groundout. Fresh out of the batters' box, Garcia gave up a leadoff single to Ausmus, who dropped a flyball into shallow center. When Adam Everett hit a grounder to third, the White Sox cleaned the bases with a double play. Backe hustled down to first as he grounded out to end the inning.

Despite the sprint to first base, Backe retired the top of the Chicago order in order in the top of the sixth. After Biggio failed in his attempt to bunt for a hit, Taveras hit a line drive into right for a single. Berkman then drew a four-pitch walk from Garcia. Taveras and Berkman pulled off a double steal as Ensberg struck out. With the count 2-0 on Lamb, Chicago opted to intentionally walk him to load the bases. To the disappointment of the Houston crowd, Lane struck out to end the inning before the Astros could score.

Two outs into the top of the seventh, CF-R Aaron Rowand mustered a single off a line drive hit into center. Crede then knocked a flyball off the scoreboard in left field for a double that moved Rowand to third. Uribe struck out to end the inning, making the White Sox wonder whether they should have sent Rowand. With only the accompaniment of a single cello rather than his large band, Lyle Lovett provided a not unpleasant rendition of the typically maudlin "God Bless America" during the seventh inning stretch.

Although Houston had no one on base when Backe's spot in the lineup came up two outs into the bottom of the seventh, the Astros pinch-hit for him with right-handed hitter Jeff Bagwell. Bagwell grounded out, ending the inning with the game still scoreless. Considering Backe's excellent performance to that point, his pitch count of a flat 100, the bullpen's heavy workout the night before as well as its recent unsteadiness, and the questionable status of Roger Clemens for Game 5, I would have thought twice about pulling Backe in most offensive situations. Given the unfavorable two-out, no one on situation, I definitely would have let him hit for himself. Instead, RHP Brad Lidge entered the game in the top of the eighth.

Pinch-hitting for Garcia, left-handed hitter Willie Harris led off with a line drive single into left. Podsednik moved Harris to second with a sacrifice bunt, and he advanced to third when switch-hitter Carl Everett grounded out to second while pinch-hitting for Iguchi. Up next, Dye hit a grounder up the middle for a single, driving in Harris for the first run of the game. Lidge struck out Konerko to end the inning, but the White Sox entered the bottom of the eighth up 1-0.

RHP Cliff Politte received the ball for Chicago in the bottom of the eighth. Biggio caught a break when C-L A.J. Pierzynski and Crede let a foul pop up drop between them, but he subsequently grounded out. Politte then caught Taveras on the hands with an inside pitch, giving him first base. Nevertheless the sore appendage did not prevent Taveras from taking second when Politte's first pitch to Berkman went wild. With first base open, Chicago intentionally walked Berkman to bring up Ensberg. Ensberg hit a flyball to Rowand in deep center, allowing Taveras to tag up and take third while Berkman remained at first. When the White Sox brought in LHP Neal Cotts to pitch to Lamb, Houston pinch-hit with switch-hitter Jose Vizcaino, who grounded out to end the inning.

Leading off the ninth, Pierzynksi hit a line drive into the right field corner for a double. Lidge then struck out Rowand and Crede, and Uribe grounded out, keeping the game within reach for the Astros going into the bottom of the ninth.

RHP Bobby Jenks took the mound for Chicago, but his spell seemed broken as Lane dropped a flyball single into shallow center. Ausmus then moved him to second with a sacrifice bunt, putting a tie 180 feet away. Pinch-hitting for Adam Everett, right-handed hitter Chris Burke hit a high flyball that drifted into the first row of seats as the stands began to jut into left field. Uribe followed the ball to the wall where he made the catch and then fell into the crowd, emerging with the ball still in his glove. The game ended with Palmerio grounding out to first, giving the White Sox's their first World Series win in 87 years.

Jermaine Dye received the World Series MVP. During the Series, Dye hit .263 with a .364 OBP and .368 SLG on 5 H, including 2 2B, with a 3:3 BB:K and 1/1 SB% in 19 AB. He scored three runs and received three RBI.